LILRB2 (clone 2G7E11), anti-human
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In stock
SKU
BT-MCA2784
Catalog Number: BT-MCA2784
Size(s): 50μL, 100μL
Isotype: Mouse IgG2a
Reactivity: human
Application(s): WB, FCM
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG2a
Reactivity: human
Application(s): WB, FCM
Datasheet
Request Information
Background:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Area: Immunology
Synonyms: ILT4, LIR2, CD85D, ILT-4, LIR-2, MIR10, MIR-10
Immunogen: Purified recombinant fragment of human LILRB2 (AA: 51-184) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage:
4°C|-20°C for long term storage
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Area: Immunology
Synonyms: ILT4, LIR2, CD85D, ILT-4, LIR-2, MIR10, MIR-10
Immunogen: Purified recombinant fragment of human LILRB2 (AA: 51-184) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage:
4°C|-20°C for long term storage
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