LILRB2 Polyclonal Antibody

Background:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Research Area: Immunology

Synonyms:
LILRB2, CD85D, ILT-4, ILT4, LIR-2, LIR2, MIR-10, MIR10

Immunogen: Recombinant fusion protein of human LILRB2 (NP_005865.3).

Swissprot: Q8N423
Gene ID: 10288

Calculated MW: 51 kDa/55 kDa/64 kDa/65 kDa
Observed MW: 65 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.