LIMK-1/2 (phospho Thr508/505) Polyclonal Antibody

Background:
LIM domain kinase 1(LIMK1) Homo sapiens There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog

Alternative Names:
LIMK1, LIMK, LIM domain kinase 1, LIMK-1, LIMK2, LIM domain kinase 2, LIMK-2

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human LIMK-1/2 (phospho Thr508/505)

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 72

GeneID: LIMK1/LIMK2

Storage: -20°C/1 year

NOTE: For Research Use Only