LIMK2 antibody (clone 2H2-E11), anti-human
€435.00
In stock
SKU
AC-AT2717a
Catalog Number: AC-AT2717a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IF, E
Request Information AC-AT2717a">Request Information
Background:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
Other Names:
LIM domain kinase 2, LIMK-2, LIMK2
Antigen Type:
Recombinant Protein
Gene Name: LIMK2
Gene ID: 3985
NCBI Accession: NP_001026971.1;NP_005560.1;NP_057952.1
Primary Accession: P53671
Other Accession: BC013051
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
Other Names:
LIM domain kinase 2, LIMK-2, LIMK2
Antigen Type:
Recombinant Protein
Gene Name: LIMK2
Gene ID: 3985
NCBI Accession: NP_001026971.1;NP_005560.1;NP_057952.1
Primary Accession: P53671
Other Accession: BC013051
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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