LIMS1 polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms: PINCH, PINCH-1, PINCH1

Cellular Location: Cell junction Cell membrane Cytoplasmic side Peripheral membrane protein focal adhesion

Immunogen:
Recombinant protein of human LIMS1

Gene Symbol: LIMS1

Gene ID: 3987

Swiss prot: P48059

Calculated MW: 37kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.