LIMS1 Polyclonal Antibody

Background:
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cardiovascular, Signal Transduction

Synonyms:
2310016J22Rik, 4921524A02Rik, AI507642, AU021743, AW551584, C430041B13Rik, LIM and senescent cell antigen like domains 1, LIM and senescent cell antigen-like-containing domain protein 1, LIM zinc finger domain containing 1, LIM-type zinc finger domains 1, Lims1, LIMS1, Lims1l, Particularly interesting new Cys His protein 1, Particularly interesting new Cys His protein, Particularly interesting new Cys-His protein 1, PINCH 1, PINCH, PINCH-1, PINCH1, Renal carcinoma antigen NY REN 48, Renal carcinoma antigen NY-REN-48, senescent cell antigen, wu:fc32c03, zgc:112533

Immunogen: Recombinant protein of human LIMS1

Swissprot: P48059
Gene Accession: NP_004978

Calculated MW: 37 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-47912/sc-47915/sc-47914/sc-67177