LIMS1 Polyclonal Antibody

Background:
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cardiovascular, Signal Transduction

Synonyms:
LIMS1, PINCH, PINCH-1, PINCH1

Immunogen: Recombinant fusion protein of human LIMS1 (NP_001180417.1).

Swissprot: P48059
Gene ID: 3987

Calculated MW: 37 kDa/38 kDa/41 kDa/44 kDa
Observed MW: 37 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.