LIN28B polyclonal (C-term), anti-human
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In stock
SKU
AC-AP1485b
Catalog Number: AC-AP1485b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB14267
Applications: FC, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB14267
Applications: FC, WB
Datasheet
Request Information
Background:
Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.
Other Names:
Protein lin-28 homolog B, Lin-28B, LIN28B, CSDD2
Target/Specificity:
This LIN28B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-250 amino acids from the C-terminal region of human LIN28B.
Antigen Region:
218-250
Antigen Type: Synthetic Peptide
Gene Name: LIN28B
Gene ID: 389421
Primary Accession: Q6ZN17
NCBI Accession: NP_001004317.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.
Other Names:
Protein lin-28 homolog B, Lin-28B, LIN28B, CSDD2
Target/Specificity:
This LIN28B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-250 amino acids from the C-terminal region of human LIN28B.
Antigen Region:
218-250
Antigen Type: Synthetic Peptide
Gene Name: LIN28B
Gene ID: 389421
Primary Accession: Q6ZN17
NCBI Accession: NP_001004317.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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