LINGO1  polyclonal, anti-human, mouse, rat, chicken

Protein Family: Receptors and Channels,

Pathway and Disease: Cell Growth and Death, Signaling Molecules and Interaction

Description:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) is the functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for inhibition of axonal regeneration by myelin-associated factors. LINGO1 is also a negative regulator of oligodentrocyte differentiation and axonal myelination. LINGO1 acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.

Alternate Names: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat and immunoglobulin-domain containing protein 1, Leucine-rich neuronal protein 6A, Leucine-rich repeat neuronal protein 1, LINGO1, Lingo-1, LERN1, LRRN6A

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500

Accession No.: Q96FE5

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human LINGO1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.