LITAF polyclonal, anti-human, mouse

Background:
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.

Synonyms: PIG7, SIMPLE, TP53I7

Cellular Location: Cytoplasmic side Lysosome membrane Peripheral membrane protein

Immunogen:
Recombinant protein of human LITAF

Gene Symbol: LITAF

Gene ID: 9516

Swiss prot: Q99732

Calculated MW: 17kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IP 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.