LKB1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor Smith et al.(1999) found that the mouse Lkb1 gene encodes a protein showing strong sequence similarity to human LKB1. Karuman et al.(2001) demonstrated that LKB1 physically associates with p53(191170) and regulates specific p53-dependent apoptosis pathways. Jenne et al.(1998) determined that the STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction. Smith et al.(1999) found that the mouse Lkb1 gene consists of 10 exons covering approximately 15 kb.

Description:
Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase STK11 (STK11) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
hLKB1 antibody, Liver kinase B1 antibody, LKB1 antibody, PJS antibody, Polarization related protein LKB1 antibody, Renal carcinoma antigen NY-REN-19 antibody, Serine/Threonine Kinase 11 antibody, Serine/threonine protein kinase 11 antibody, Serine/threonine protein kinase LKB1 antibody, Serine/threonine protein kinase STK11 antibody, Serine/threonine-protein kinase 11 antibody, Serine/threonine-protein kinase LKB1 antibody, Serine/threonine-protein kinase XEEK1 antibody, Stk11 antibody, STK11_HUMAN antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human LKB1(421-433aa SSKIRRLSACKQQ), different from the mouse sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.