LMNB1 Polyclonal Antibody

Background:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).

Research Area: Cancer, Cell Biology, Signal Transduction, Tags and Cell Markers

Synonyms:
ADLD, lamin B1, Lamin-B1, LMN, LMN2, LMNB, Lmnb1, LMNB1, MGC111419, OTTHUMP00000159218

Immunogen: Fusion protein of human LMNB1

Swissprot: P20700
Gene Accession: BC012295

Calculated MW: 67 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:100-1:300, ELISA 1:2000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.