LOX 1 polyclonal, anti-human

Quantity: 100 µg

Background:
OLR1(oxidized low density lipoprotein(lectin-like) receptor 1) also called CLEC8A, LOX-1, SCARE1, is a receptor protein which belongs to the C-type lectin superfamily. The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein(OxLDL). The OLR1 gene is mapped on 12p13.2. Incubation of the cells with LDL had no effect on LOX1 expression, but incubation with OxLDL resulted in a dose-dependent increase in LOX1 mRNA and protein expression; however, very high concentrations of OxLDL caused a decrease in OxLDL expression, perhaps indicating toxic effects on endothelial cells. LOX1 was also expressed in macrophages, but not in vascular smooth muscle cells. The findings suggested a role for LOX1 in the pathophysiology of atherosclerotic cardiovascular disease. LOX1 expression was detected in all choroidal neovascular membranes, regardless of structure, whereas there was no evidence of LOX1 within the posterior segments of normal eyes. LOX1 plays an active role in the pathogenesis of choroidal neovascularization, especially in ARMD.

Description:
Rabbit IgG polyclonal antibody for Oxidized low-density lipoprotein receptor 1 (OLR1) detection. Tested with WB in Human.

Synonyms:
C-type lectin domain family 8 member A antibody, CLEC8A antibody, hLOX 1 antibody, hLOX-1 antibody, Lectin like oxidized LDL receptor 1 antibody, Lectin like oxLDL receptor 1 antibody, Lectin type oxidized LDL receptor 1 antibody, Lectin-like oxidized LDL receptor 1 antibody, Lectin-like oxLDL receptor 1 antibody, Lectin-type oxidized LDL receptor 1 antibody, LOX-1 antibody, LOXIN antibody, Olr1 antibody, OLR1_HUMAN antibody, Ox LDL receptor 1 antibody, Ox-LDL receptor 1 antibody, Oxidised low density lipoprotein(lectin like) receptor 1 antibody, Oxidized low density lipoprotein receptor 1 antibody, Oxidized low density lipoprotein receptor 1 soluble form antibody, Oxidized low-density lipoprotein receptor 1 antibody, SCARE1 antibody, Scavenger receptor class E, member 1 antibody, SLOX1 antibody, soluble form antibody, SR-EI antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human LOX 1(1-16aa MTFDDLKIQTVKDQPD).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.