LOX-1 polyclonal, anti-human, mouse

Background:
The oxidized low density lipoprotein (lectin-like) receptor-1, Ox-LDL R-1, is a type II membrane protein that is a member of the C-type lectin family and acts as a cell-surface receptor for oxidized low density lipoprotein (Ox-LDL). Ox-LDL plays a role in early atherosclerosis, which includes the transformation of monocyte-derived macrophages to foam cells in atherosclerotic lesions. The binding of Ox-LDL to Ox-LDL R-1 may also trigger the activation of the NFkB signal transduction pathway. Ox-LDL R-1, also designated scavenger receptor class E, member 1 (SCARE1), lectin-type oxidized LDL receptor 1 (LOX-1), and CLEC8A), is expressed by vascular endothelial cells, smooth muscle cells and macrophages. It is expressed endogenously as a precursor form with N-linked high mannose carbohydrate chains and as a mature form due to further glycosylation. The N-linked glycosylation of Ox-LDL R-1 appears to be necessary for adequate transportation to the cell surface and efficient ligand binding.

Alternative Name:
Ox-LDL receptor 1, LOX-1, Lectin-like oxLDL receptor 1, hLOX-1, OLR1, CLEC8A, LOX1, C-type lectin domain family 8 member A, CLEC8A, hLOX 1, hLOX-1, Lectin like oxidized LDL receptor 1, Lectin like oxLDL receptor 1, Lectin type oxidized LDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, low density lipoprotein oxidized, receptor 1, LOX-1, LOXIN, Olr1, OLR1, Ox LDL receptor 1, Ox-LDL receptor 1, Oxidised low density lipoprotein (lectin like) receptor 1, Oxidized low density lipoprotein receptor 1, Oxidized low density lipoprotein receptor 1 soluble form, Oxidized low-density lipoprotein receptor 1, SCARE1, Scavenger receptor class E, member 1, SLOX1, soluble form, SR-EI,

Application Dilution:
WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: LOX-1 polyclonal antibody detects endogenous levels of LOX-1 protein.

Immunogen:
Recombinant protein.

MW: 31 kDa

Swiss-Prot: P78380(Human) Q9EQ09(Mouse)

Purification & Purity:
Protein affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.