LPA (clone 8F6A9,8H5C5), anti-human

Protein Family: Enzymes

Pathway and Disease: Lipid Metabolism

Description:
LPA (Lipoprotein, Lp(a), Apo(a)) is the main constituent of lipoprotein(a) (lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/gp330. Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation.

Alternate Names: Apolipoprotein(a), Apo(a), Lp(a), LPA, AK38, APOA

Application Notes: E: 1:10000; WB: 1:500-1:2000; IHC: 1:200-1:1000

Accession No.: P08519

Antigen: Purified recombinant fragment of LPA (aa4330-4521) expressed in E. coli.

Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.