LPHN2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60779
Background:
The Latrophilin family of G protein-coupled receptors consists of three members, latrophilin-1, 2 and 3, each of which displays distinct tissue distribution and function. Latrophilin-1, the most characterized member of this family, acts as a receptor for a-latrotoxin, a component of venom from the black widow spider. Binding of a-latrotoxin to latrophilin-1 triggers synaptic vesicle exocytosis via both Ca2+-dependent and -independent mechanisms, resulting in vesicle depletion. Latrophilin-1 is abundant in brain and present in endocrine cells. Latrophilin-3 is also brain-specific, whereas latrophilin-2 expression is ubiquitous.
Alternative Name:
Latrophilin-2, Calcium-independent alpha-latrotoxin receptor 2, CIRL-2, Latrophilin homolog 1, Lectomedin-1, LPHN2, KIAA0786, LEC1, LPHH1
Application Dilution: WB: 1:500~1:1000
Specificity: LPHN2 polyclonal antibody detects endogenous levels of LPHN2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human LPHN2
MW: ~ 163 kDa
Swis Prot.: O95490
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The Latrophilin family of G protein-coupled receptors consists of three members, latrophilin-1, 2 and 3, each of which displays distinct tissue distribution and function. Latrophilin-1, the most characterized member of this family, acts as a receptor for a-latrotoxin, a component of venom from the black widow spider. Binding of a-latrotoxin to latrophilin-1 triggers synaptic vesicle exocytosis via both Ca2+-dependent and -independent mechanisms, resulting in vesicle depletion. Latrophilin-1 is abundant in brain and present in endocrine cells. Latrophilin-3 is also brain-specific, whereas latrophilin-2 expression is ubiquitous.
Alternative Name:
Latrophilin-2, Calcium-independent alpha-latrotoxin receptor 2, CIRL-2, Latrophilin homolog 1, Lectomedin-1, LPHN2, KIAA0786, LEC1, LPHH1
Application Dilution: WB: 1:500~1:1000
Specificity: LPHN2 polyclonal antibody detects endogenous levels of LPHN2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human LPHN2
MW: ~ 163 kDa
Swis Prot.: O95490
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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