LRAT polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5783
Background:
Lecithin retinol acyltransferase (LRAT) is a membrane bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A which generates all-trans-retinyl esters (tREs) in the liver, some extrahepatic tissues, such as the lung, and retinal pigmented epithelium. LRAT can also exchange palmitoyl groups between RPE65, a tRE binding protein essential for vision, and tREs, which is important for the operation of the visual pathway. LRAT is essential for the dietary mobilization, transport, and storage of vitamin A as well as the synthesis of the visual pigment chromophore. LRAT monomers interact in membranes to form homodimers through disulfide bond formation. A loss of LRAT correlates with an early onset severe retinal dystrophy and severe retinyl ester deprivation, while a reduction in LRAT expression may be associated with invasive bladder cancer.
Alternative Name:
Lecithin retinol acyltransferase, Phosphatidylcholine--retinol O-acyltransferase, Phosphatidylcholine-retinol O-acyltransferase
Application Dilution: WB: 1:500~1:1000, IF: 1:200
Specificity: LRAT polyclonal antibody detects endogenous levels of LRAT protein.
Immunogen:
Synthetic peptide, corresponding to the 148-193 of Human LRAT.
MW: ~ 25 kDa (Monomer), 50 kDa (Dimer)
Swis Prot.: O95237
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Lecithin retinol acyltransferase (LRAT) is a membrane bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A which generates all-trans-retinyl esters (tREs) in the liver, some extrahepatic tissues, such as the lung, and retinal pigmented epithelium. LRAT can also exchange palmitoyl groups between RPE65, a tRE binding protein essential for vision, and tREs, which is important for the operation of the visual pathway. LRAT is essential for the dietary mobilization, transport, and storage of vitamin A as well as the synthesis of the visual pigment chromophore. LRAT monomers interact in membranes to form homodimers through disulfide bond formation. A loss of LRAT correlates with an early onset severe retinal dystrophy and severe retinyl ester deprivation, while a reduction in LRAT expression may be associated with invasive bladder cancer.
Alternative Name:
Lecithin retinol acyltransferase, Phosphatidylcholine--retinol O-acyltransferase, Phosphatidylcholine-retinol O-acyltransferase
Application Dilution: WB: 1:500~1:1000, IF: 1:200
Specificity: LRAT polyclonal antibody detects endogenous levels of LRAT protein.
Immunogen:
Synthetic peptide, corresponding to the 148-193 of Human LRAT.
MW: ~ 25 kDa (Monomer), 50 kDa (Dimer)
Swis Prot.: O95237
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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