LRDD Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13884b
Background:
LRDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.
Other Names:
p53-induced death domain-containing protein 1, Leucine-rich repeat and death domain-containing protein, PIDD1, LRDD, PIDD
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13884b was selected from the C-term region of LRDD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PIDD1 {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:16491}
Gene ID: 55367
Primary Accession: Q9HB75
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
LRDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.
Other Names:
p53-induced death domain-containing protein 1, Leucine-rich repeat and death domain-containing protein, PIDD1, LRDD, PIDD
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13884b was selected from the C-term region of LRDD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PIDD1 {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:16491}
Gene ID: 55367
Primary Accession: Q9HB75
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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