LRP5 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. It is mapped to 11q13.2. LRP5 is a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with diabetes mellitus type 1 in humans. This protein plays a key role in skeletal homeostasis. In addition to that, the binding of axin to LRP5 is an important part of the Wnt signal transduction pathway, and it also acts as a target for the inhibitory effects of Dickkopf, another developmental protein, on Wnt signaling.

Description:
Rabbit IgG polyclonal antibody for Low-density lipoprotein receptor-related protein 5 (LRP5) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
BMND1 antibody, EVR1 antibody, EVR4 antibody, HBM antibody,, HGNC:6697 antibody, Low density lipoprotein receptor related protein 5 antibody, Low density lipoprotein receptor related protein 7 antibody, Low-density lipoprotein receptor-related protein 5 antibody, LR3 antibody, LRP-5 antibody, Lrp5 antibody, LRP7 antibody, OPPG antibody, OPS antibody, OPTA1 antibody, Osteoporosis pseudoglioma syndrome antibody, VBCH2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human LRP5(1201-1215aa IHAVEEVSLEEFSAH), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human LRP5(1201-1215aa IHAVEEVSLEEFSAH), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat.
Predicted to work with: human.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.