LRP6 Antibody (C-term T1546) Blocking Peptide
€363.00
In stock
SKU
AC-BP6158a
Background:
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Other Names:
Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6158a was selected from the C-term region of human LRP6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: LRP6
Gene ID: 4040
Primary Accession: O75581
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Other Names:
Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6158a was selected from the C-term region of human LRP6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: LRP6
Gene ID: 4040
Primary Accession: O75581
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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