LRP6 Polyclonal Antibody
€0.00
In stock
SKU
E-AB-17347
Catalog Number: E-AB-17347
Isotype: Rabbit IgG
Reactivity: human, mouse
Applications: IHC,ELISA
Datasheet, Questions? Contact us!
Isotype: Rabbit IgG
Reactivity: human, mouse
Applications: IHC,ELISA
Datasheet, Questions? Contact us!
Background:
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Research Area: Cancer, Signal transduction, Stem cells
Synonyms:
ADCAD2, C030016K15Rik, Cd, FLJ90062, FLJ90421, LDL receptor related protein 6, Low density lipoprotein receptor related protein 6, Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6, LRP6, OTTHUMP00000238979, OTTHUMP00000238980, OTTHUMP00000238982, STHAG7
Immunogen: Synthetic peptide of human LRP6
Swissprot: O75581
Gene Accession: BC143725
Purification Method: Affinity purification
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration: 1.4 mg/mL
Dilution: IHC 1:40-200, ELISA 1:2000-10000
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Alternative for product with catalog number:
sc-17982/sc-17984/sc-134462/sc-15399
Citation(s):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206209/
https://www.frontiersin.org/articles/10.3389/fonc.2018.00470/abstract
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Research Area: Cancer, Signal transduction, Stem cells
Synonyms:
ADCAD2, C030016K15Rik, Cd, FLJ90062, FLJ90421, LDL receptor related protein 6, Low density lipoprotein receptor related protein 6, Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6, LRP6, OTTHUMP00000238979, OTTHUMP00000238980, OTTHUMP00000238982, STHAG7
Immunogen: Synthetic peptide of human LRP6
Swissprot: O75581
Gene Accession: BC143725
Purification Method: Affinity purification
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Concentration: 1.4 mg/mL
Dilution: IHC 1:40-200, ELISA 1:2000-10000
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Alternative for product with catalog number:
sc-17982/sc-17984/sc-134462/sc-15399
Citation(s):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206209/
https://www.frontiersin.org/articles/10.3389/fonc.2018.00470/abstract
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