LRP6 polyclonal (C-term T1546), anti-human
€0.00
In stock
SKU
AC-AP6158a
Catalog Number: AC-AP6158a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB01837
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB01837
Applications: WB, IHC-P
Datasheet
Request Information
Background:
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Other Names:
Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6
Target/Specificity:
This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6.
Antigen Region:
1531-1560
Antigen Type: Synthetic Peptide
Gene Name: LRP6
Gene ID: 4040
Primary Accession: O75581
NCBI Accession: NP_002327.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Other Names:
Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6
Target/Specificity:
This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6.
Antigen Region:
1531-1560
Antigen Type: Synthetic Peptide
Gene Name: LRP6
Gene ID: 4040
Primary Accession: O75581
NCBI Accession: NP_002327.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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