LRRC8A polyclonal(C-term), anti-human, mouse

Background:
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Other Names:
Volume-regulated anion channel subunit LRRC8A, Leucine-rich repeat-containing protein 8A, Swelling protein 1, LRRC8A, KIAA1437, LRRC8, SWELL1

Target/Specificity:
This LRRC8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 782-810 amino acids from the C-terminal region of human LRRC8A.

Antigen Region:
782-810

Antigen Type: Synthetic Peptide

Gene Name: LRRC8A {ECO:0000303|PubMed:22532330, ECO:0000312|HGNC:HGNC:19027}
Gene ID: 56262
Primary Accession: Q8IWT6
NCBI Accession: NP_001120716.1;NP_001120717.1;NP_062540.2
Other Accession: Q4V8I7; Q80WG5; NP_062540.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.