LRRFIP1 polyclonal, anti-human
€484.00
In stock
SKU
254437
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
LRRFIP1, also known as GC-binding factor 2 (GCF2), is a 738 amino acid transcriptional repressor that mainly plays a cytoskeletal role. It is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a beta-catenin-dependent pathway.
Alternate Names: Leucine rich repeat interacting protein 1, TAR RNA-interacting protein, TRIP, FLAP-1, FLIIAP1, GC-binding factor 2, GCF2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_001131022
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human LRRFIP1.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
LRRFIP1, also known as GC-binding factor 2 (GCF2), is a 738 amino acid transcriptional repressor that mainly plays a cytoskeletal role. It is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a beta-catenin-dependent pathway.
Alternate Names: Leucine rich repeat interacting protein 1, TAR RNA-interacting protein, TRIP, FLAP-1, FLIIAP1, GC-binding factor 2, GCF2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_001131022
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human LRRFIP1.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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