LRRK2 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP21200b
Catalog Number: AC-AP21200b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB50924
Applications: WB, IHC, FC
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB50924
Applications: WB, IHC, FC
Datasheet
Request Information
Background:
Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosphorylates PRDX3. May also have GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
Other Names:
Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin, LRRK2, PARK8
Target/Specificity:
This LRRK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2171-2207 amino acids from the C-terminal region of human LRRK2.
Gene Name: LRRK2
Gene ID: 120892
Primary Accession: Q5S007
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosphorylates PRDX3. May also have GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
Other Names:
Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin, LRRK2, PARK8
Target/Specificity:
This LRRK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2171-2207 amino acids from the C-terminal region of human LRRK2.
Gene Name: LRRK2
Gene ID: 120892
Primary Accession: Q5S007
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
|---|
Write Your Own Review