LRRTM3 polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Nervous and Sensory Systems, Neurodegenerative Disorders, Signaling Molecules and Interaction

Description:
The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer’s disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.

Alternate Names: Leucine-rich repeat transmembrane neuronal protein 3, LRRTM3

Application Notes: Cat. No. 254421 only detects the larger LRRTM3 isoform (581 aa). E: 1:1,000-1:5,000; WB: 1:1,000-1:2,000; IHC: 1:100-1:500; IF: 1:20-1:50

Accession No.: NP_821079

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human LRRTM3.

Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.