LRSAM1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71366
Background:
LRSAM1 (leucine-rich repeat and sterile α motif-containing protein 1), also known as Tsg101-associated ligase, is a 723 amino acid E3 ubiquitin-protein ligase that mediates the monoubiquination of tsg 101, a regulator of vesicular trafficking. This leads to inactivation of the sorting of endocytic and exocytic cargos, such as EGF receptors and HIV-1 viral proteins. Mutations within the LRSAM1 gene have been identified in patients with Charcot-Marie-Tooth disease. There are three isoforms of LRSAM1 that are produced as a result of alternative splicing events.
Alternative Name:
TAL, UNQ6496/PRO21356, E3 ubiquitin-protein ligase LRSAM1
Application Dilution: WB: 1:500 - 1:2000
Specificity: LRSAM1 polyclonal antibody detects endogenous levels of LRSAM1 protein.
Immunogen:
Recombinant protein of human LRSAM1.
MW: ~ 84 kDa
Swis Prot.: Q6UWE0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
LRSAM1 (leucine-rich repeat and sterile α motif-containing protein 1), also known as Tsg101-associated ligase, is a 723 amino acid E3 ubiquitin-protein ligase that mediates the monoubiquination of tsg 101, a regulator of vesicular trafficking. This leads to inactivation of the sorting of endocytic and exocytic cargos, such as EGF receptors and HIV-1 viral proteins. Mutations within the LRSAM1 gene have been identified in patients with Charcot-Marie-Tooth disease. There are three isoforms of LRSAM1 that are produced as a result of alternative splicing events.
Alternative Name:
TAL, UNQ6496/PRO21356, E3 ubiquitin-protein ligase LRSAM1
Application Dilution: WB: 1:500 - 1:2000
Specificity: LRSAM1 polyclonal antibody detects endogenous levels of LRSAM1 protein.
Immunogen:
Recombinant protein of human LRSAM1.
MW: ~ 84 kDa
Swis Prot.: Q6UWE0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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