LSD1 (aa 450-500) polyclonal, anti-human, mouse, primate, chimpanzee, bovine antibody
€215.00
In stock
SKU
AC-ABV11114-50
Catalog Number: AC-ABV11114-50
Size: 50 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 50 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
LSD1 the first known lysine-specific histone demethylase, is an 866 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports s µggest that that LSD1 plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2, LSD1 serves as a novel biomarker predictive for prostate cancer.
Other Names:
Lysine-specific histone demethylase 1A (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2)
Primary Accession: O60341
Gene Name: KDM1A
Gene ID: 23028
LSD1 the first known lysine-specific histone demethylase, is an 866 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports s µggest that that LSD1 plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2, LSD1 serves as a novel biomarker predictive for prostate cancer.
Other Names:
Lysine-specific histone demethylase 1A (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2)
Primary Accession: O60341
Gene Name: KDM1A
Gene ID: 23028
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