LSM1 polyclonal, anti-human
€305.00
In stock
SKU
BS60034
Background:
Sm and Sm-like (LSm) proteins form donut-shaped heptameric complexes that are involved in various steps of RNA metabolism. LSm proteins facilitate RNA protein interactions and structural changes that are required during ribosomal subunit assembly. LSm1, also designated U6 snRNA-associated Sm-like protein or small nuclear ribonuclear CaSm, binds specifically to the 3'-terminal U-tract of U6 snRNA. Human LSm1 localizes to the cytoplasm in small, discrete foci. These foci are also the localization site for the mRNA decapping enzyme Dcp1/2 and the exonuclease Xm1. LSm1 is naturally overexpressed in pancreatic cancer as well as in certain breast cancer cell lines. The downregulation of LSm1 is involved in the progression of prostate cancer.
Alternative Name:
U6 snRNA-associated Sm-like protein LSm1, Cancer-associated Sm-like, Small nuclear ribonuclear CaSm, CASM
Application Dilution: WB: 1:500~1:1000
Specificity: LSM1 polyclonal antibody detects endogenous levels of LSM1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human LSM1.
MW: ~ 15 kDa
Swis Prot.: O15116
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Sm and Sm-like (LSm) proteins form donut-shaped heptameric complexes that are involved in various steps of RNA metabolism. LSm proteins facilitate RNA protein interactions and structural changes that are required during ribosomal subunit assembly. LSm1, also designated U6 snRNA-associated Sm-like protein or small nuclear ribonuclear CaSm, binds specifically to the 3'-terminal U-tract of U6 snRNA. Human LSm1 localizes to the cytoplasm in small, discrete foci. These foci are also the localization site for the mRNA decapping enzyme Dcp1/2 and the exonuclease Xm1. LSm1 is naturally overexpressed in pancreatic cancer as well as in certain breast cancer cell lines. The downregulation of LSm1 is involved in the progression of prostate cancer.
Alternative Name:
U6 snRNA-associated Sm-like protein LSm1, Cancer-associated Sm-like, Small nuclear ribonuclear CaSm, CASM
Application Dilution: WB: 1:500~1:1000
Specificity: LSM1 polyclonal antibody detects endogenous levels of LSM1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human LSM1.
MW: ~ 15 kDa
Swis Prot.: O15116
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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