LSP1 polyclonal, anti-human, mouse, rat

Background:
pp52 (human) or LSP1 (murine) is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

Alternative Name:
pp52, LSP1, 47 kDa actin binding protein, 47 kDa actin-binding protein, 52 kDa phosphoprotein, F actin binding and cytoskeleton associated protein, Leufactin (leukocyte F-actin binding protein), Leufactin, Leukocyte F actin binding protein, Leukocyte specific protein 1, LSP 1, Lsp1, LSP1, Lymphocyte specific antigen WP34, Lymphocyte specific protein 1, Lymphocyte specific protein pp52, Lymphocyte-specific antigen WP34, Lymphocyte-specific protein 1, OTTHUMP00000014138, OTTHUMP00000014139, OTTHUMP00000014140, OTTHUMP00000069612, OTTHUMP00000069614, OTTHUMP00000069615, OTTHUMP00000069616, pp52, Protein pp52, S37 protein, WP 34, WP34,

Application Dilution:
WB:1:1,000
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: LSP1 polyclonal antibody detects endogenous levels of LSP1 protein.

Immunogen:
recombinant protein

MW: 52 kDa

Swiss-Prot: P33241(Human) P19973(Mouse) Unigene:101608(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.