LTB Polyclonal Antibody

Background:
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Cancer, Immunology, Signal Transduction

Synonyms:
LT beta, LT-beta, Ltb, lymphotoxin beta, Lymphotoxin-beta, p33, TNF-C, TNFC, TNFC, TNFSF3, Tumor necrosis factor C, Tumor necrosis factor ligand superfamily member 3

Immunogen: Synthetic peptide of human LTB

Swissprot: Q06643
Gene Accession: NP_002332

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.9 mg/mL
Dilution: IHC 1:30-1:150

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-23561/sc-20655