LTbetaR (clone 3C8), anti-mouse
€264.00
In stock
SKU
ARP-23-B0041
Catalog Number: 23-B0041
Size: 25 µg
Isotype: Rat IgG1 kappa
Size: 25 µg
Isotype: Rat IgG1 kappa
Decription:
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Synonyms: Lymphotoxin-beta Receptor, Tumor Necrosis Factor Receptor 2 Related Protein, Tumor Necrosis Factor C Receptor, Tumor Necrosis Factor Receptor Superfamily Member 3, TNFRSF3
Clone: 3C8
Isotype: Rat IgG1 kappa
Immunogen: Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).
Reactivity: mouse
Specificity: Recognizes mouse LTbetaR.
Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.
Applications: Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Synonyms: Lymphotoxin-beta Receptor, Tumor Necrosis Factor Receptor 2 Related Protein, Tumor Necrosis Factor C Receptor, Tumor Necrosis Factor Receptor Superfamily Member 3, TNFRSF3
Clone: 3C8
Isotype: Rat IgG1 kappa
Immunogen: Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).
Reactivity: mouse
Specificity: Recognizes mouse LTbetaR.
Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.
Applications: Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
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