LTbetaR (clone 4H8 WH2), anti-mouse

Decription:
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Synonyms: Lymphotoxin-beta Receptor, Tumor Necrosis Factor Receptor 2 Related Protein, Tumor Necrosis Factor C Receptor, Tumor Necrosis Factor Receptor Superfamily Member 3, TNFRSF3

Clone: 4H8 WH2

Isotype: Rat IgG2a

Immunogen: Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).

Reactivity: mouse

Specificity: Recognizes mouse LTbetaR.

Form: Purified, in PBS containing 10% glycerol.

Applications:
Flow Cytometry
Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)