LTbetaR Functional mAb (clone 4H8 WH2) preservative free, anti-mouse
€345.00
In stock
SKU
AC-ADP0021-U0100
Catalog Number: AC-ADP0021-U0100
Size: 100 µg
Isotype: Rat IgG2a
Applications: FC
Datasheet
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Size: 100 µg
Isotype: Rat IgG2a
Applications: FC
Datasheet
Request Information
Background:
The LT-β-R activates two different NF-kappa pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LT-β-R activates the classical NF-kappa (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1-β-. However, LT-β-R, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Other Names:
Lymphotoxin-β Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
The LT-β-R activates two different NF-kappa pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LT-β-R activates the classical NF-kappa (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1-β-. However, LT-β-R, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Other Names:
Lymphotoxin-β Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
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