LXR-B polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
254212
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer’s disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele.
Alternate Names: LXR-B, Liver X receptor B, LXRB, nuclear receptor subfamily 1 group H member 2, NR1H2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: P55055
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human LXR-B.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer’s disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele.
Alternate Names: LXR-B, Liver X receptor B, LXRB, nuclear receptor subfamily 1 group H member 2, NR1H2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: P55055
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human LXR-B.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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