LXRα polyclonal, anti-human, mouse, rat

Background:
Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

Alternative Name:
NR1H3, LXRA, Liver X receptor alpha, LXR a, LXRA, NR1H3, NR1H3, Nuclear receptor subfamily 1 group H member 3, Oxysterols receptor LXR alpha, Oxysterols receptor LXR-alpha, RLD 1, RLD1,

Application Dilution:
WB:1:500
IHC:1：50-1：200
FC:1:50-1:100

Specificity: LXRα polyclonal antibody detects endogenous levels of LXRα protein.

Immunogen:
recombinant protein

MW: 50 kDa

Swiss-Prot: Q13133(Human) Q9Z0Y9(Mouse) Q62685(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.