LYN (clone 2H8D7), anti-human
€539.00
In stock
SKU
252697
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Signaling Molecules and Interaction
Description:
Lyn (p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3. Lyn is a member of the src family of non-receptor protein tyrosine kinases, predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).
Alternate Names: Lck/Yes-related novel protein tyrosine kinase, V-yes-1, Yamaguchi sarcoma viral related oncogene homolog, p53Lyn, p56Lyn, JTK8, FLJ26625
Application Notes: WB: 1:500-1:2000
Accession No.: P07948
Antigen: Purified recombinant fragment of LYN expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Lyn (p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3. Lyn is a member of the src family of non-receptor protein tyrosine kinases, predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).
Alternate Names: Lck/Yes-related novel protein tyrosine kinase, V-yes-1, Yamaguchi sarcoma viral related oncogene homolog, p53Lyn, p56Lyn, JTK8, FLJ26625
Application Notes: WB: 1:500-1:2000
Accession No.: P07948
Antigen: Purified recombinant fragment of LYN expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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