LYRIC polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
MTDH (Metadherin), also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene. AEG-1 is involved in HIF-1alpha mediated angiogenesis. AEG-1 also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays very important role in RISC and miRNA functions. AEG-1 induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis. Late SV40 factor (LSF/TFCP2) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). AEG-1 acts as an oncogene in melanoma, malignant glioma, breast cancer and hepatocellular carcinoma. It is highly expressed in these cancers and helps in progression and development of these cancers. It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells.

Description:
Rabbit IgG polyclonal antibody for Protein LYRIC (MTDH) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
3D3 antibody, 3D3/LYRIC antibody, AEG 1 antibody, AEG-1 antibody, AEG1 antibody, Astrocyte elevated gene 1 antibody, Astrocyte elevated gene-1 protein antibody, LYRIC antibody, LYRIC/3D3 antibody, LYRIC_HUMAN antibody, Lysine rich CEACAM1 associated protein antibody, Lysine rich CEACAM1 co isolated protein antibody, Lysine-rich CEACAM1 co-isolated protein antibody, Metadherin antibody, Metastasis adhesion protein antibody, MTDH antibody, Protein LYRIC antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human LYRIC recombinant protein (Position: D101-Q270). Human LYRIC shares 94% amino acid (aa) sequence identity with both mouse and rat LYRIC.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.