M TLR5 polyclonal (N-term), anti-human, mouse
€0.00
In stock
SKU
AC-AP1505a
Catalog Number: AC-AP1505a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2681
Applications: WB, IHC-P
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2681
Applications: WB, IHC-P
Datasheet
Request Information
Background:
TLR5, a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. It also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has an unique TLR5 haplotype and a lower expression of TRL5.
Other Names:
Toll-like receptor 5, Tlr5
Target/Specificity:
This Mouse TLR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-102 amino acids from the N-terminal region of mouse TLR5.
Antigen Region:
71-102
Antigen Type: Synthetic Peptide
Gene Name: Tlr5
Gene ID: 53791
Primary Accession: Q9JLF7
NCBI Accession: NP_058624.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
TLR5, a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. It also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has an unique TLR5 haplotype and a lower expression of TRL5.
Other Names:
Toll-like receptor 5, Tlr5
Target/Specificity:
This Mouse TLR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-102 amino acids from the N-terminal region of mouse TLR5.
Antigen Region:
71-102
Antigen Type: Synthetic Peptide
Gene Name: Tlr5
Gene ID: 53791
Primary Accession: Q9JLF7
NCBI Accession: NP_058624.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
|---|
Write Your Own Review