M3K12 Polyclonal Antibody

Background:
mitogen-activated protein kinase kinase kinase 12(MAP3K12) Homo sapiens This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010],

Immunogen: Synthesized peptide derived from human protein . at AA range: 730-810

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 94

GeneID: MAP3K12 ZPK

Storage: -20°C/1 year

NOTE: For Research Use Only