M6PR polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS8108
Background:
CD-MPR (cation-dependent mannose-6-phosphate receptor) is an oligomeric transmembrane protein that plays a critical role in the intracellular delivery of phosphorylated lysosomal enzymes from the trans-Golgi network (TGN). Intracellular trafficking of CD-MPR is mediated by sorting signals in its 67 amino acid cytoplasmic tail, which prevent it from entering the lysosome, where it would be degraded. CD-MPR is predominantly expressed in mouse testicular germ cells and shows differentiated expression during maturation of rat spermatozoa. Increased expression of CD-MPR in Alzheimer’s disease and the location of the CD-MPR gene next to a region on chromosome 12 which is possibly linked to the disease indicate that CD-MPR may play a role in Alzheimer’s disease.
Alternative Name:
Cation-dependent mannose-6-phosphate receptor, CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46, M6PR, MPR46, MPRD
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: M6PR polyclonal antibody detects endogenous levels of M6PR protein.
Immunogen:
Recombinant full length Human M6PR.
MW: ~ 31 kDa
Swis Prot.: P20645
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
CD-MPR (cation-dependent mannose-6-phosphate receptor) is an oligomeric transmembrane protein that plays a critical role in the intracellular delivery of phosphorylated lysosomal enzymes from the trans-Golgi network (TGN). Intracellular trafficking of CD-MPR is mediated by sorting signals in its 67 amino acid cytoplasmic tail, which prevent it from entering the lysosome, where it would be degraded. CD-MPR is predominantly expressed in mouse testicular germ cells and shows differentiated expression during maturation of rat spermatozoa. Increased expression of CD-MPR in Alzheimer’s disease and the location of the CD-MPR gene next to a region on chromosome 12 which is possibly linked to the disease indicate that CD-MPR may play a role in Alzheimer’s disease.
Alternative Name:
Cation-dependent mannose-6-phosphate receptor, CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46, M6PR, MPR46, MPRD
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: M6PR polyclonal antibody detects endogenous levels of M6PR protein.
Immunogen:
Recombinant full length Human M6PR.
MW: ~ 31 kDa
Swis Prot.: P20645
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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