MACC1 rabbit polyclonal, anti-human, mouse

Backgroud: MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],function:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly found in the cytoplasm in non-metastasizing tumors.,tissue specificity:Preferentially expressed in metastasizing tumors.,

Synonyms: MACC1, Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5

Gene Name: MACC1

Gene ID: 346389

SwissProt ID: Q6ZN28

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.