Mad2L1 polyclonal, anti-human

Quantity: 100 µg

Background:
Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene. This gene belongs to the MAD2 family. It is mapped to 4q27. MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The protein has two highly different native conformations, an inactive open conformation that cannot bind CDC20 and that predominates in cytosolic monomers, and an active closed conformation. It is required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment.

Description:
Rabbit IgG polyclonal antibody for Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) detection. Tested with WB in Human.

Synonyms:
Homolog of MAD2 S cerevisiae antibody, HsMAD 2 antibody, HsMAD2 antibody, Human mitotic feedback control protein Madp2 antibody, MAD 2 antibody, MAD 2A antibody, MAD2 antibody, MAD2 like 1 antibody, MAD2 like protein 1 antibody, MAD2 mitotic arrest deficient like 1 antibody, MAD2-like protein 1 antibody, MAD2A antibody, Mad2l1 antibody, MD2L1_HUMAN antibody, Mitotic arrest deficient 2-like protein 1 antibody, Mitotic arrest deficient like 1 antibody, Mitotic arrest deficient yeast homolog antibody, Mitotic arrest deficient yeast homolog like 1 antibody, Mitotic spindle assembly checkpoint protein antibody, Mitotic spindle assembly checkpoint protein MAD2A antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Mad2L1 recombinant protein (Position: A2-D205). Human Mad2L1 shares 94% amino acid (aa) sequence identity with mouse Mad2L1.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.