MADCAM-1 polyclonal, anti-mouse, rat

Protein Family: CAM Ligands, Cell Adhesion Molecules

Pathway and Disease: Cell Motility, Immune System, Signaling Molecules and Interaction

Description:
Mucosal addressin cell adhesion molecule 1 (MADCAM-1) is a cell adhesion leukocyte receptor expressed by mucosal venules. MADCAM-1 helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. MADCAM-1 binds to integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. The isoform 2, lacking th emucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strenghthening, independent of L-selectin binding.

Alternate Names: Mucosal addressin cell adhesion molecule 1, MAdCAM-1, MAdCAM-1, MADCAM1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:200-1:500

Accession No.: Q61826

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region (extracellular) of mouse MADCAM-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.