MADH7 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
SMAD7(Mother against decapentaplegic drosophila homolog of 7), also known as MADH7 or SMA- AND MAD-RELATED PROTEIN 7, is a protein that in humans is encoded by the SMAD7 gene. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of ligands. By somatic cell hybrid analysis, Topper et al.(1997) mapped the MADH7 gene to human chromosome 18. Topper et al.(1997) demonstrated that MADH7 and MADH6 could form complexes in endothelial cells. MADH7 was induced in cultured vascular endothelium by fluid mechanical forces and was capable of modulating endothelial gene expression in response to both humoral and biomechanical stimuli in vitro. By FISH, Roijer et al.(1998) refined the localization to 18q21.1. Lallemand et al.(2001) showed that cells stably expressing SMAD7 had increased susceptibility to apoptosis induced by TGFB, TNFA, serum withdrawal, or loss of cell adhesion.

Description:
Rabbit IgG polyclonal antibody for Mothers against decapentaplegic homolog 7 (SMAD7) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
FLJ16482 antibody, hSMAD 7 antibody, hSMAD7 antibody, MAD(mothers against decapentaplegic Drosophila) homolog 7 antibody, MAD antibody, Mad homolog 7 antibody, MAD homolog 8 antibody, MAD mothers against decapentaplegic homolog 7 antibody, MADH 7 antibody, MADH 8 antibody, MADH6 antibody, MADH8 antibody, Mothers Against Decapentaplegic Drosophila Homolog of 6 antibody, Mothers Against Decapentaplegic Drosophila Homolog of 7 antibody, Mothers against decapentaplegic homolog 7 antibody, Mothers against decapentaplegic homolog 8 antibody, Mothers against DPP homolog 7 antibody, Mothers against DPP homolog 8 antibody, SMA- AND MAD-RELATED PROTEIN 7 antibody, SMAD 7 antibody, SMAD antibody, SMAD family member 7 antibody, SMAD, mothers against DPP homolog 7(Drosophila) antibody, SMAD, mothers against DPP homolog 7 antibody, SMAD6 antibody, SMAD7 antibody, SMAD7_HUMAN antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human MADH7(375-389aa YSLQRPNDHEFMQQP), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human MADH7(375-389aa YSLQRPNDHEFMQQP), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.