MAFA polyclonal, anti-rat, human

Quantity: 100 µg

Background:
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA plays a key role in coordinating and controlling the level of insulin gene expression in islet beta cells. It is located in 8q24.3. The intracellular domain of MAFA contains a single immunoreceptor tyrosine-based inhibitory motif (ITIM), which classifies MAFA as a member of an inhibitory receptor superfamily. The inhibitory capacity of MAFA is best defined in mast cells, where MAFA keeps in check the antigen-induced (i.e. Fc epsilon RI-induced) secretion ofinflammatory mediators.

Description:
Rabbit IgG polyclonal antibody for Transcription factor MafA (MAFA) detection. Tested with WB in Human, Rat.

Synonyms:
HMafA antibody, Mafa antibody, MAFA_HUMAN antibody, Pancreatic beta cell specific transcriptional activator antibody, Pancreatic beta-cell-specific transcriptional activator antibody, RIPE3b1 antibody, Transcription factor MafA antibody, Transcription factor RIPE3b1 antibody, v maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) antibody, v maf musculoaponeurotic fibrosarcoma oncogene homolog A antibody, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human MAFA(136-167aa EDAVEALIGSGHHGAHHGAHHPAAAAAYEAFR), identical to the related mouse sequence.A synthetic peptide corresponding to a sequence in the middle region of human MAFA(136-167aa EDAVEALIGSGHHGAHHGAHHPAAAAAYEAFR), identical to the related mouse sequence.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: rat.
Predicted to work with: human.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.