MAGEA5 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6167a
Background:
MAGEA5 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita. This gene appeared to be the most weakly expressed member of the family, at fewer than 2 copies per cell. It was isolated from adult muscle.
Other Names:
Melanoma-associated antigen 5, Cancer/testis antigen 15, CT15, MAGE-5 antigen, MAGEA5, MAGE5
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6167a was selected from the N-term region of human MAGEA5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MAGEA5P (HGNC:6803)
Gene ID: 100533997
Primary Accession: P43359
Other Accession: NP_066387
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
MAGEA5 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita. This gene appeared to be the most weakly expressed member of the family, at fewer than 2 copies per cell. It was isolated from adult muscle.
Other Names:
Melanoma-associated antigen 5, Cancer/testis antigen 15, CT15, MAGE-5 antigen, MAGEA5, MAGE5
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6167a was selected from the N-term region of human MAGEA5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MAGEA5P (HGNC:6803)
Gene ID: 100533997
Primary Accession: P43359
Other Accession: NP_066387
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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