MAGEL2 Polyclonal Antibody

Background:
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.

Research Area: Cancer, Immunology

Synonyms:
Mage-l2, MAGE-like 2, MAGE-like protein 2, MAGEL2, melanoma antigen-like gene 2, NDNL1, Necdin like protein 1, necdin-like 1, nM15, ns7, Protein nM15, PWLS

Immunogen: Synthetic peptide of human MAGEL2

Swissprot: Q9UJ55
Gene Accession: NP_061939

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.8 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-164952/sc-164951