MAL Polyclonal Antibody

Background:
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.

Research Area: Cancer, Cell biology, Neuroscience

Synonyms:
mal, MAL protein gene, Mal T-cell differentiation protein, MAL, MALGENE, MPV17, Myelin and lymphocyte protein, T-cell differentiation protein MAL, T-lymphocyte maturation-associated protein, VIP17

Immunogen: Synthetic peptide of human MAL

Swissprot: P21145
Gene Accession: NP_002362

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-46171/sc-46169/sc-66978/sc-48761