MALT1 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS6789
Background:
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21.32, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. The MALT1-API2 fusion protein activates NF˚B and creates a signaling pathway, which is influenced by this Bcl10-MALT1 complex. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
Alternative Name:
Caspase like protein, caspase-like protein, DKFZp434L132, MALT 1, MALT associated translocation, MALT lymphoma associated translocation, MALT lymphoma-associated translocation, Malt1, MALT1, MLT 1, MLT, MLT1, Mucosa associated lymphoid tissue lymphoma translocation gene 1, Mucosa associated lymphoid tissue lymphoma translocation protein 1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Paracaspase,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: MALT1 polyclonal antibody detects endogenous levels of MALT1 protein.
Immunogen:
Recombinant full length Human MALT1.
MW: ~ 92 kDa
Swis Prot.: Q9UDY8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21.32, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. The MALT1-API2 fusion protein activates NF˚B and creates a signaling pathway, which is influenced by this Bcl10-MALT1 complex. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
Alternative Name:
Caspase like protein, caspase-like protein, DKFZp434L132, MALT 1, MALT associated translocation, MALT lymphoma associated translocation, MALT lymphoma-associated translocation, Malt1, MALT1, MLT 1, MLT, MLT1, Mucosa associated lymphoid tissue lymphoma translocation gene 1, Mucosa associated lymphoid tissue lymphoma translocation protein 1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Paracaspase,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: MALT1 polyclonal antibody detects endogenous levels of MALT1 protein.
Immunogen:
Recombinant full length Human MALT1.
MW: ~ 92 kDa
Swis Prot.: Q9UDY8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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